Study of the safety of transplantation of cultured autologous human chondroblasts.
Bull Exp Biol Med
; 148(1): 126-31, 2009 Jul.
Article
em En
| MEDLINE
| ID: mdl-19902113
ABSTRACT
Study of tumorigenic activity of cultured human chondroblasts intended for autologous transplantations showed that subcutaneous injection of human chondroblast suspension in a dose of 10(7)cells/0.2 ml did not cause the development of tumors in C.B-17 SCID immunodeficient mice over 12 weeks. Subcutaneous formations of compact cartilaginous consistency persisted at the site of chondroblast transplantation in all animals; these formations gradually shrank. Subcutaneous injection of tumor cell suspension (A204 human embryonic sarcoma) to C.B-17 SCID mice under the same conditions caused 100% development of tumors (poorly differentiated sarcomas) by day 14.
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Base de dados:
MEDLINE
Assunto principal:
Transplante de Células
/
Condrócitos
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article