Isolation, structure and biological activities of platensimycin B4 from Streptomyces platensis.
J Antibiot (Tokyo)
; 62(12): 699-702, 2009 Dec.
Article
em En
| MEDLINE
| ID: mdl-19911028
ABSTRACT
Platensimycin and platencin are inhibitors of FabF and FabF/H bacterial fatty acid synthesis enzymes, respectively. Discovery of natural congeners provides one of the ways to understand the relationship of chemical structure and biological function. Efforts to discover the natural analogs of platensimycin by chemical screening led to the isolation of platensimycin B(4), a glucoside congener of platensimycin. This analog showed significantly attenuated activity and critically defined the limited binding space around the aromatic ring and established the importance of the free phenolic and carboxyl group for the activity.
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Base de dados:
MEDLINE
Assunto principal:
Streptomyces
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Adamantano
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Inibidores Enzimáticos
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Aminobenzoatos
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Anilidas
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article