Germinal center reutilization by newly activated B cells.
J Exp Med
; 206(13): 2907-14, 2009 Dec 21.
Article
em En
| MEDLINE
| ID: mdl-19934021
ABSTRACT
Germinal centers (GCs) are specialized structures in which B lymphocytes undergo clonal expansion, class switch recombination, somatic hypermutation, and affinity maturation. Although these structures were previously thought to contain a limited number of isolated B cell clones, recent in vivo imaging studies revealed that they are in fact dynamic and appear to be open to their environment. We demonstrate that B cells can colonize heterologous GCs. Invasion of primary GCs after subsequent immunization is most efficient when T cell help is shared by the two immune responses; however, it also occurs when the immune responses are entirely unrelated. We conclude that GCs are dynamic anatomical structures that can be reutilized by newly activated B cells during immune responses.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Linfócitos B
/
Ativação Linfocitária
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Centro Germinativo
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article