Breakthrough zygomycosis on posaconazole prophylaxis after allogeneic stem cell transplantation.
Transpl Infect Dis
; 12(3): 261-4, 2010 Jun.
Article
em En
| MEDLINE
| ID: mdl-19954497
ABSTRACT
Antifungal prophylaxis with posaconazole (POS) has been shown to decrease the mortality associated with invasive fungal infections in high-risk patients. We report on a patient, with severe graft-versus-host disease after allogeneic stem cell transplantation, who developed proven pneumonia due to Rhizopus microsporus after 40 days of POS prophylaxis (fasting serum levels 691-904 ng/mL). Despite combination treatment with liposomal amphotericin B and POS for 39 days, the patient died from pulmonary hemorrhage. This case highlights the need for continued awareness of breakthrough zygomycosis in patients receiving POS.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pneumonia
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Rhizopus
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Transplante Homólogo
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Triazóis
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Transplante de Células-Tronco
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Mucormicose
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Antifúngicos
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article