[Pathogenesis and clinical significance of interleukin-8 and tumor necrosis factor-alpha in cervicitis].
Zhonghua Yi Xue Za Zhi
; 89(24): 1684-6, 2009 Jun 23.
Article
em Zh
| MEDLINE
| ID: mdl-19957526
ABSTRACT
OBJECTIVE:
To investigate the relationship between local immune status of vagina and the occurrence of disease in patients with cervicitis.METHODS:
ELISA were used to detect the level of interleukin (IL)-8 and tumor necrosis factor (TNF)alpha in vaginal douche of patients with cervicitis due to ureaplasma urealyticum, mycoplasma hominis, chlamydia trachomatis, neisseria gonorrhoeae and cervical erosion.RESULTS:
Compared with the control group, the level of IL-8 in vaginal douche of patients with mycoplasma hominis cervicitis, chlamydia trachomatis cervicitis and neisseria gonorrhoeae cervicitis was significantly higher and there was significant difference ng/L 371 +/- 34, 369 +/- 31, 339 +/- 36, vs 341 +/- 32, 338 +/- 33, 316 +/- 24, (all P < 0.01). Comparing the level of IL-8 in vaginal douche of patients with ureaplasma urealyticum cervicitis and cervical erosion with that of control group, there was no statistical difference (all P > 0.05). The level of TNF-alpha in vaginal douche of each group was remarkably higher than that of control group except for patients with cervical erosion. And statistically significant difference was found between them (all P < 0.01).CONCLUSION:
With regards to the pathogenesis of cervicitis, local immune mechanism of vagina plays an important role in the occurrence of cervicitis. The role of IL-8 in pathogenesis of mycoplasma hominis cervicitis, chlamydia trachomatis cervicitis and neisseria gonorrhoeae cervicitis is likely to be more important.
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Base de dados:
MEDLINE
Assunto principal:
Vagina
/
Cervicite Uterina
/
Interleucina-8
/
Fator de Necrose Tumoral alfa
Idioma:
Zh
Ano de publicação:
2009
Tipo de documento:
Article