Feature-level MALDI-MS characterization of in situ-synthesized peptide microarrays.
Langmuir
; 26(3): 1456-9, 2010 Feb 02.
Article
em En
| MEDLINE
| ID: mdl-20028116
ABSTRACT
Characterizing the chemical composition of microarray features is a difficult yet important task in the production of in situ-synthesized microarrays. Here, we describe a method to determine the chemical composition of microarray features, directly on the feature. This method utilizes nondiffusional chemical cleavage from the surface along with techniques from MALDI-MS tissue imaging, thereby making the chemical characterization of high-density microarray features simple, accurate, and amenable to high-throughput.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Análise Serial de Proteínas
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article