Flavones suppress type I IL-4 receptor signaling by down-regulating the expression of common gamma chain.
FEBS Lett
; 584(4): 775-9, 2010 Feb 19.
Article
em En
| MEDLINE
| ID: mdl-20040389
ABSTRACT
Immunoglobulin E (IgE) production is induced by interleukin (IL)-4 signaling mediated by type I IL-4 receptor (IL-4R) in B cells. We found that flavones inhibited IL-4-induced epsilon germline transcription which is essential for IgE class switching, and the phosphorylation of signal transducer and activator of transcription 6, janus kinase 3, and IL-4Ralpha, whereas IL-4 signaling mediated through type II IL-4R was unaffected by flavones. Furthermore, flavones reduced the expression of common gamma chain, a characteristic constituent subunit of type I IL-4R, suggesting that flavones suppress type I IL-4R signaling.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
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Flavonas
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Subunidade gama Comum de Receptores de Interleucina
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Receptores Tipo I de Interleucina-4
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article