Annulation of thioimidates and vinyl carbodiimides to prepare 2-aminopyrimidines, competent nucleophiles for intramolecular alkyne hydroamination. Synthesis of (-)-crambidine.
J Am Chem Soc
; 132(6): 1802-3, 2010 Feb 17.
Article
em En
| MEDLINE
| ID: mdl-20095555
ABSTRACT
A convergent synthesis of (-)-crambidine is reported. The sequence capitalizes on two novel key transformations, including a [4+2] annulation of thioimidates with vinyl carbodiimides and an alkyne hydroamination employing 2-aminopyrimidine nucleophiles.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pirimidinas
/
Compostos de Espiro
/
Carbodi-Imidas
/
Guanidina
/
Alcinos
/
Imidoésteres
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article