A facile and efficient synthesis of 3,3-dimethyl isopropylidene proline from (+)-3-carene.
J Org Chem
; 75(4): 1285-8, 2010 Feb 19.
Article
em En
| MEDLINE
| ID: mdl-20108962
ABSTRACT
A highly efficient and practical route to 3,4-isopropylidene proline I, starting from (+)-3-carene, was developed. The three continuous stereocenters were constructed using the inherent chirality of the starting natural product 2. The overall yield for the 12-step synthesis is 34%. The optimized sequence leading to 1 has been successfully applied on a multigram scale, thereby establishing the practicality of this route.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Prolina
/
Monoterpenos
/
Compostos Alílicos
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article