The histone demethylase UTX enables RB-dependent cell fate control.
Genes Dev
; 24(4): 327-32, 2010 Feb 15.
Article
em En
| MEDLINE
| ID: mdl-20123895
ABSTRACT
Trimethylation of histone H3 on Lys 27 (H3K27me3) is key for cell fate regulation. The H3K27me3 demethylase UTX functions in development and tumor suppression with undefined mechanisms. Here, genome-wide chromatin occupancy analysis of UTX and associated histone modifications reveals distinct classes of UTX target genes, including genes encoding Retinoblastoma (RB)-binding proteins. UTX removes H3K27me3 and maintains expression of several RB-binding proteins, enabling cell cycle arrest. Genetic interactions in mammalian cells and Caenorhabditis elegans show that UTX regulates cell fates via RB-dependent pathways. Thus, UTX defines an evolutionarily conserved mechanism to enable coordinate transcription of a RB network in cell fate control.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Diferenciação Celular
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Regulação da Expressão Gênica
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Histona Desmetilases com o Domínio Jumonji
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Proteínas de Ligação a Retinoblastoma
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article