Stability of protein pharmaceuticals: an update.
Pharm Res
; 27(4): 544-75, 2010 Apr.
Article
em En
| MEDLINE
| ID: mdl-20143256
ABSTRACT
In 1989, Manning, Patel, and Borchardt wrote a review of protein stability (Manning et al., Pharm. Res. 6903-918, 1989), which has been widely referenced ever since. At the time, recombinant protein therapy was still in its infancy. This review summarizes the advances that have been made since then regarding protein stabilization and formulation. In addition to a discussion of the current understanding of chemical and physical instability, sections are included on stabilization in aqueous solution and the dried state, the use of chemical modification and mutagenesis to improve stability, and the interrelationship between chemical and physical instability.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Preparações Farmacêuticas
/
Proteínas
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article