Chronic DLL4 blockade induces vascular neoplasms.
Nature
; 463(7282): E6-7, 2010 Feb 11.
Article
em En
| MEDLINE
| ID: mdl-20147986
ABSTRACT
Delta-like 4 (DLL4)-mediated Notch signalling has emerged as an attractive target for cancer therapy. However, the potential side effects of blocking this pathway remain uncertain. Here we show that chronic DLL4 blockade causes pathological activation of endothelial cells, disrupts normal organ homeostasis and induces vascular tumours, raising important safety concerns.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Vasculares
/
Peptídeos e Proteínas de Sinalização Intracelular
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Proteínas de Membrana
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Antineoplásicos
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article