Dynamic T cell migration program provides resident memory within intestinal epithelium.
J Exp Med
; 207(3): 553-64, 2010 Mar 15.
Article
em En
| MEDLINE
| ID: mdl-20156972
ABSTRACT
Migration to intestinal mucosa putatively depends on local activation because gastrointestinal lymphoid tissue induces expression of intestinal homing molecules, whereas skin-draining lymph nodes do not. This paradigm is difficult to reconcile with reports of intestinal T cell responses after alternative routes of immunization. We reconcile this discrepancy by demonstrating that activation within spleen results in intermediate induction of homing potential to the intestinal mucosa. We further demonstrate that memory T cells within small intestine epithelium do not routinely recirculate with memory T cells in other tissues, and we provide evidence that homing is similarly dynamic in humans after subcutaneous live yellow fever vaccine immunization. These data explain why systemic immunization routes induce local cell-mediated immunity within the intestine and indicate that this tissue must be seeded with memory T cell precursors shortly after activation.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Linfócitos T
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Vacina contra Febre Amarela
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Memória Imunológica
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Mucosa Intestinal
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article