Control of metabolism and signaling of simple bioactive sphingolipids: Implications in disease.
Prog Lipid Res
; 49(4): 316-34, 2010 Oct.
Article
em En
| MEDLINE
| ID: mdl-20193711
ABSTRACT
Simple bioactive sphingolipids include ceramide, sphingosine and their phosphorylated forms sphingosine 1-phosphate and ceramide 1-phosphate. These molecules are crucial regulators of cell functions. In particular, they play important roles in the regulation of angiogenesis, apoptosis, cell proliferation, differentiation, migration, and inflammation. Decoding the mechanisms by which these cellular functions are regulated requires detailed understanding of the signaling pathways that are implicated in these processes. Most importantly, the development of inhibitors of the enzymes involved in their metabolism may be crucial for establishing new therapeutic strategies for treatment of disease.
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Base de dados:
MEDLINE
Assunto principal:
Esfingolipídeos
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Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article