CD20-depleting therapy in autoimmune diseases: from basic research to the clinic.
J Intern Med
; 267(3): 260-77, 2010 Mar.
Article
em En
| MEDLINE
| ID: mdl-20201920
ABSTRACT
The B lymphocyte-associated antigen CD20 is becoming an important immunotherapy target for autoimmune diseases, although its biological function has not been defined. Besides rheumatoid arthritis, growing experience with B cell-depleting therapy indicates that it may be effective in Sjögren's syndrome, dermatomyositis-polymyositis, systemic lupus erythematosus and some types of vasculitides. However, controlled clinical trials are still lacking for some of these indications. Infection has not been seen as a major limitation to this therapy, but reports of progressive multifocal leukoencephalopathy in an extremely small number of patients are of concern. Here, we review the therapeutic actions of anti-CD20 antibodies, and the recent and ongoing clinical trials with CD20-depleting therapy in autoimmune diseases.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doenças Autoimunes
/
Linfócitos B
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Antígenos CD20
/
Fatores Imunológicos
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Anticorpos Monoclonais
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article