Isolation and characterization of antineoplastic alkaloids from Catharanthus roseus L. Don. cultivated in Egypt.
Afr J Tradit Complement Altern Med
; 6(2): 118-22, 2009 Mar 07.
Article
em En
| MEDLINE
| ID: mdl-20209002
ABSTRACT
Vinblastine and vincristine (the antileukemic agents) were isolated, in a pure form, from Catharanthus roseus L. Don., cultivated in Egypt, by several chromatographic techniques. Five modified methods for the preparation of total alkaloids were carried out. All the isolated mixtures were evaluated by HPLC and HPTLC analyses. The antineoplastic alkaloids; vinblastine and vincristine, were isolated by the use of vacuum liquid chromatographic column on silica gel aluminium oxide (11) mixed bed vacuum liquid chromatography (VLC), Charcoal column, and finally purified by centrifugally accelerated radial chromatography (Chromatotrone).
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Base de dados:
MEDLINE
Assunto principal:
Vimblastina
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Vincristina
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Extratos Vegetais
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Catharanthus
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Antineoplásicos Fitogênicos
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article