[Genetics of Alzheimer's disease]. / Genética en la enfermedad de Alzheimer.
Rev Neurol
; 50(6): 360-4, 2010 Mar 16.
Article
em Es
| MEDLINE
| ID: mdl-20309834
ABSTRACT
INTRODUCTION AND DEVELOPMENT. Alzheimer's disease (AD), the leading cause of dementia, is a complex disorder in which genetic and environmental factors interact. Three genes -the amyloid precursor protein (APP) and the presenilin 1 and 2 (PSEN1 and PSEN2)- have been linked to autosomal dominant forms of AD. Besides, a fourth gene -the apolipoprotein E gene (APOE)- seems to be the only major genetic factor related to late-onset sporadic and familial AD cases. Although more than a thousand studies have been performed to date, little is known about other genetic factors leading to this devastating dementia. Nevertheless, the last three years have witnessed a surge in genetic research of AD due to the implementation of novel technologies enabling large-scale genetic analyses. CONCLUSION. This review provides a summary of current knowledge about AD in the genetic field.
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Base de dados:
MEDLINE
Assunto principal:
Doença de Alzheimer
Idioma:
Es
Ano de publicação:
2010
Tipo de documento:
Article