[Occult lymph node metastasis in the middle and lower third rectal cancer after neoadjuvant radiotherapy].
Zhonghua Wei Chang Wai Ke Za Zhi
; 13(3): 189-92, 2010 Mar.
Article
em Zh
| MEDLINE
| ID: mdl-20336536
ABSTRACT
OBJECTIVE:
To investigate the occult lymph node metastasis in the middle and lower third rectal cancer after neoadjuvant radiotherapy.METHODS:
From June 2003 to December 2006, 74 rectal cancer patients received neoadjuvant radiotherapy (30 Gy/10 f/2 w, CACA-CRC-001) and underwent total mesorectal excision (TME) two weeks later. Fat clearance technique was used in all the samples. Occult lymph node metastasis was detected in the mesorectum using the anti-CK antibody.RESULTS:
In total 1883 retrieved lymph nodes, 172 metastasis lymph nodes were harvested by HE examination with the mean diameter [(4.9+/-2.6) mm] being larger than that (2.7+/-1.4) mm of the 1711 negative nodes (P<0.01). In HE negative nodes, occult metastasis was found in 40 lymph nodes (2.33%) from 24 patients. Most of these nodes were less than 5 mm (90.0%) with a mean diameter of (3.2+/-1.2)mm, smaller than those of HE-positive metastasis nodes (P<0.01). Occult metastasis was found in 23.1% (9/39) of HE-negative patients. Occult metastasis incidence was higher in patients with HE-positive nodes (42.8%,P<0.01). No correlation of lymph node occult metastasis with tumor differentiation, age, or surgical procedures was found. There was no significant difference in recurrence-free survival between ypN(0) patients with and without occult metastasis (P=0.157).CONCLUSION:
It is not necessary to include occult lymph node metastasis in the TNM staging in patients with ypN(0) rectal cancer.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Retais
/
Linfonodos
/
Metástase Linfática
Idioma:
Zh
Ano de publicação:
2010
Tipo de documento:
Article