Sirolimus-based immunosuppression in kidney transplantation for type 2 diabetic nephropathy.
Urol Int
; 84(3): 301-4, 2010.
Article
em En
| MEDLINE
| ID: mdl-20389159
ABSTRACT
INTRODUCTION:
Kidney transplantation is the best replacement therapy of type 2 diabetic patients and recently similar graft and patient survival between diabetic and nondiabetic recipients has been reported. However, standard immunosuppressive protocols are lacking. We present our experience with sirolimus-based immunosuppression in a population of 24 type 2 diabetic patients who underwent a kidney transplantation. PATIENTS ANDMETHODS:
From January 2001 to December 2006, 396 kidney transplantations were performed. Twenty-four patients had type 2 diabetes mellitus as a cause of end-stage renal disease. They were randomized in two groups thirteen patients (group A) received an immunosuppressive treatment with sirolimus, low-dose tacrolimus and steroids, while 11 patients (group B) received sirolimus, mycophenolate mofetil and steroids.RESULTS:
Clinical characteristics were similar between the two groups. A slightly better kidney functionality was observed in group B patients. There were neither acute rejection episodes nor severe infectious complications in both groups. One patient in each group underwent a foot amputation. Graft and patient survival was 100% for both groups at a median follow-up of 29 months.CONCLUSIONS:
Sirolimus-based immunosuppression is safe and efficacious in type 2 diabetic patients who underwent a kidney transplantation, allowing a better glucose metabolism control.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Terapia de Imunossupressão
/
Transplante de Rim
/
Sirolimo
/
Diabetes Mellitus Tipo 2
/
Nefropatias Diabéticas
/
Imunossupressores
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article