Exploration of the HDAC2 foot pocket: Synthesis and SAR of substituted N-(2-aminophenyl)benzamides.
Bioorg Med Chem Lett
; 20(10): 3142-5, 2010 May 15.
Article
em En
| MEDLINE
| ID: mdl-20392638
ABSTRACT
A series of N-(2-amino-5-substituted phenyl)benzamides (3-21) were designed, synthesized and evaluated for their inhibition of HDAC2 and their cytotoxicity in HCT116 cancer cells. Multiple compounds from this series demonstrated time-dependent binding kinetics that is rationalized using a co-complex crystal structure of HDAC2 and N-(4-aminobiphenyl-3-yl)benzamide (6).
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Benzamidas
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Histona Desacetilase 2
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Inibidores de Histona Desacetilases
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article