Synthesis of 3-amino-thiochromanes from 4-benzyl 2-thiazolines, via an unprecedented intramolecular electrophilic aromatic substitution.
Org Biomol Chem
; 8(11): 2520-1, 2010 Jun 07.
Article
em En
| MEDLINE
| ID: mdl-20411200
ABSTRACT
A one-pot synthesis of various N-substituted 3-amino-thiochromanes from 4-benzyl-2-methyl thiazoline via a thiazolinium salt is described. The obtained 3-amino-thiochromanes are enantiopure, as their precursors derive from chiral 2-aminoalcohols. The reaction involves the formation of a disulfide, which subsequently takes part in an unprecedented intramolecular electrophilic aromatic substitution.
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1
Base de dados:
MEDLINE
Assunto principal:
Tiazóis
/
Compostos Bicíclicos Heterocíclicos com Pontes
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article