[Susceptibility to antibiotics of Escherichia coli isolated from community-acquired urinary tract infections]. / Sensibilité aux antibiotiques des Escherichia coli isolés d'infections urinaires communautaires.

ABSTRACT

OBJECTIVE: The authors had for aim to determine the distribution of bacterial isolates and the antibiotic susceptibility patterns of Escherichia coli from community-acquired urinary tract infections in an area covering 57,000 people (Elbeuf, Normandie, France). DESIGN: From November 2007 to October 2008, three private French laboratories consecutively collected 2344 bacteria including 1636 E. coli from outpatients. The antibiotic susceptibility of E. coli was determined using an automatized method (Vitek 2 Biomerieux). RESULTS: The global susceptibility of E. coli was ampicillin 57%; amoxicillin+clavulanic acid 73%; cefixim 96%; ceftriaxone 98%; gentamycin 96%; nalidixic acid 82%; ciprofloxacin 89%; fosfomycin 98%; nitrofurantoin 96% and cotrimoxazole 81%. The susceptibility of E. coli to ciprofloxacin was higher in 15- to 65-year-old female patients (94%) than for older female (85%) or male patients (80%). CONCLUSIONS: In the Elbeuf area, third generation cephalosporins, aminoglycosides, nitrofurantoin, and fosfomycin were the most effective on E. coli isolated from community-acquired urinary tract infections. Fluoroquinolones were more active in 15- to 65-year-old female patients than in male patients and in female patients over 65 years of age. The rates of acquired resistance were related to the level of antibiotic prescription in the various populations.