Caged mitochondrial uncouplers that are released in response to hydrogen peroxide.
Tetrahedron
; 66(13): 2384-2389, 2010 Mar 27.
Article
em En
| MEDLINE
| ID: mdl-20418941
ABSTRACT
Caged versions of the most common mitochondrial uncouplers (proton translocators) have been prepared that sense the reactive oxygen species (ROS) hydrogen peroxide to release the uncouplers 2,4-dinitrophenol (DNP) and carbonylcyanide p-trifluoromethoxyphenylhydrazone (FCCP) from caged states with second order rate constants of 10 (+/-0.8) M(-1) s(-1) and 64.8 (+/-0.6) M(-1) s(-1), respectively. The trigger mechanism involves conversion of an arylboronate into a phenol followed by fragmentation. Hydrogen peroxide-activated uncouplers may be useful for studying the biological process of ageing.
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MEDLINE
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En
Ano de publicação:
2010
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Article