[Combined hormono-radiotherapy in treatment of locally advanced prostate cancer].
Acta Chir Iugosl
; 56(4): 175-81, 2009.
Article
em Sr
| MEDLINE
| ID: mdl-20420017
ABSTRACT
Numerous questions regarding combined hormono-radiotherapy in the treatment of locally advanced prostate cancer still remain open. We present results of combined treatment in 133 our patients with locally advanced prostate cancer. All patients recieved hormonotherapy as neoadjuvant, concomitant with radiotherapy (tumor dose range 65-72 Gy), and adjuvant. In six months follow-up time, complete regression (CR) was noted in 120 patients (90%), partial regression (PR) in 6 (4.5%), stabile disease (SD) in 2 (1.5%) and progression of disease (PD) in 5 patients (4%). In mean follow up time of 17 months (6-77), 13 patients relapsed. Five-year time to progression was 70%. Five-year disease-free interval for CR patients was 70%. At the date of last control CR was noted in 116 patients (87%), PR in 2 patients (2%), SD in 7 patients (5%), and 8 patients (6%) had progressive disease. Second malignancy was noted in 4 patients. Multidisciplinary studies directed towards the optimisation of combined treatment are ongoing. There are no definitive conclusions.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Próstata
/
Antineoplásicos Hormonais
/
Antagonistas de Androgênios
Idioma:
Sr
Ano de publicação:
2009
Tipo de documento:
Article