Intestinal fermentation modulates postprandial acylcarnitine profile and nitrogen metabolism in a true carnivore: the domestic cat ( Felis catus).
Br J Nutr
; 104(7): 972-9, 2010 Oct.
Article
em En
| MEDLINE
| ID: mdl-20420757
ABSTRACT
N balance and postprandial acylcarnitine profile following intestinal fermentation of oligofructose and inulin were investigated in healthy cats. Two diets were tested in a crossover design:
a commercial high-protein cat food supplemented with 4 % DM oligofructose and inulin (spectrum degree of polymerisation (DP) 2-10 60 (SE 5) % DM; DP>10 28 (SE 5) % DM) as high-fermentable fibre (HFF) diet, and the same commercial diet supplemented with 4 % DM cellulose as low-fermentable fibre diet. Eight adult cats were randomly allotted to each of the two diets at intervals of 4 weeks. At the end of each testing period, faeces and urine were collected over a 5-d period, and blood samples were obtained before and at the selected time points postprandially. No differences were found for N intake, N digestibility and faecal N excretion, whereas urinary N excretion was lower when the HFF diet was fed (P = 0.044). N balance was positive in all the cats, and tended to be increased when the HFF diet was fed (P = 0.079). Propionylcarnitine concentrations (P = 0.015) and their area under the curve (AUC) (P = 0.013) were increased when the HFF diet was fed, revealing a more pronounced production and absorption of propionate. Yet, methylmalonylcarnitine concentrations and concurrent AUC were not elevated when the HFF diet was fed, indicating reduced amino acid catabolism. 3-Hydroxy-3-methylglutarylcarnitine concentrations (P = 0.026) and their AUC (P = 0.028) were also reduced when the HFF diet was fed, implying diminished use of branched-chain amino acids as well. In healthy cats, oligofructose and inulin added to a high-protein diet were suggested to reduce postprandial amino acid-induced gluconeogenesis by substitution with propionate.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Oligossacarídeos
/
Proteínas Alimentares
/
Carnitina
/
Aminoácidos
/
Mucosa Intestinal
/
Inulina
/
Nitrogênio
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article