Bioactive norditerpenoids from the soft coral Sinularia gyrosa.
Bioorg Med Chem
; 18(10): 3379-86, 2010 May 15.
Article
em En
| MEDLINE
| ID: mdl-20430633
Chemical investigations of the soft coral Sinularia gyrosa resulted in the isolation of six new norcembranolides, gyrosanolides A-F (1-6), a new norcembrane, gyrosanin A (7), and 11 known norditerpenoids 8-18. The structures of the isolated compounds were elucidated through extensive spectroscopic data and by comparison with reported data in the literature. Compounds 1-3, 7-9, 12, and 13 at concentration of 10microM did not inhibit the COX-2 protein expression, but significantly reduced the levels of the iNOS protein (55.2+/-14.6%, 18.6+/-6.7%, 10.6+/-4.6%, 66.9+/-5.2%, 10.2+/-5.1%, 17.4+/-7.2%, 47.2+/-11.9%, and 56.3+/-5.1%, respectively) by LPS stimulation. Compound 8 showed significant antiviral activity against HCMV (human cytomegalovirus) cells with an IC(50) of 1.9microg/mL.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Prostaglandina-Endoperóxido Sintases
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Antozoários
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Diterpenos
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article