Synthesis, anticoagulant and PIVKA-II induced by new 4-hydroxycoumarin derivatives.
Bioorg Med Chem
; 18(10): 3371-8, 2010 May 15.
Article
em En
| MEDLINE
| ID: mdl-20435480
ABSTRACT
The action of the coumarin-type drugs and related compounds is reviewed to their VKOR antagonistic effects. In our study, twenty 3-pyridinyl, pyrimidinyl and pyrazolyl-4-hydroxycoumarin derivatives were synthesized. A comparative in vivo (CT, PT determination) and in vitro (measurement of PIVKA-II levels) anticoagulant study with respect to warfarin showed that the synthesized compounds have different anticoagulant activities, the most prospective compounds were the 3-pyrazolyl-4-hydroxycoumarin derivatives.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Precursores de Proteínas
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Varfarina
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Protrombina
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Inibidores da Agregação Plaquetária
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4-Hidroxicumarinas
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Anticoagulantes
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article