Capillary electrophoretic and nuclear magnetic resonance studies on the opposite affinity pattern of propranolol enantiomers towards various cyclodextrins.
J Sep Sci
; 33(11): 1617-24, 2010 Jun.
Article
em En
| MEDLINE
| ID: mdl-20437416
ABSTRACT
In the present study the migration order of the propranolol enantiomers with various native CDs and neutral and charged CD derivatives was examined in capillary electrophoresis (CE). The reversal of the enantiomer migration order was observed due to sulfation of beta-CD on its primary hydroxy groups. The structures of intermolecular selector-select and temporary diastereomeric associates in solution were elucidated based on 1D rotating frame nuclear Overhauser effect spectroscopy (1D ROESY) experiments. Major structural differences were observed between the propranolol complexes with native beta-CD and heptakis(6-O-sulfo)-beta-CD.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Propranolol
/
Eletroforese Capilar
/
Ciclodextrinas
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article