Arsenic inhibits neurite outgrowth by inhibiting the LKB1-AMPK signaling pathway.
Environ Health Perspect
; 118(5): 627-34, 2010 May.
Article
em En
| MEDLINE
| ID: mdl-20439172
ABSTRACT
BACKGROUND:
Arsenic (As) is an environmental pollutant that induces numerous pathological effects, including neurodevelopmental disorders. OBJECTIVES ANDMETHODS:
We evaluated the role of the LKB1-AMPK pathway in As-induced developmental neurotoxicity using Neuro-2a (N2a) neuroblastoma cells as a model of developing neurons.RESULTS:
The addition of low concentrations of As (CONCLUSIONS:
Reduced neurite outgrowth induced by As results from deficient activation of AMPK as a consequence of a lack of activation of LKB1. Oxidative stress induced by As, especially excessive superoxide, plays a critical role in blocking the LKB1-AMPK pathway. Our studies provide insight into the mechanisms underlying As-induced developmental neurotoxicity, which is important for designing a new strategy for protecting children against this neurotoxic substance.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Arsênio
/
Poluentes Químicos da Água
/
Neuritos
/
Proteínas Serina-Treonina Quinases
/
Proteínas Quinases Ativadas por AMP
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article