Varicella zoster virus-induced hemolytic crisis in an infant with severe vitamin B 12 deficiency.
J Pediatr Hematol Oncol
; 32(4): 317-8, 2010 May.
Article
em En
| MEDLINE
| ID: mdl-20445420
ABSTRACT
BACKGROUND:
Vitamin B 12 deficiency is an uncommon disorder in infancy. Most cases are because of maternal deficiency resulting from insufficient storage and/or reduced intake and are generally seen in exclusively breast-fed infants. Accentuation of the hemolytic process has never been described in association with Varicella Zoster Virus (VZV) infections. OBSERVATION We describe a 9-months-old breast-fed infant with megaloblastic anemia secondary to maternal vitamin B 12 deficiency. He presented severe pancytopenia and regression of motor functions and developed hemolytic crisis during a VZV infection.CONCLUSIONS:
Nutritional cobalamin deficiency should be considered in anemic infants with a history of prolonged exclusive breastfeeding and delayed developmental milestones. VZV infection can trigger a hemolytic process in infants with severe megaloblastic anemia secondary to B12 deficiency. A normal mean corpuscular volume does not rule out megaloblastic anemia, when the condition is combined with severe hemolysis.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pancitopenia
/
Deficiência de Vitamina B 12
/
Herpesvirus Humano 3
/
Hemólise
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Herpes Zoster
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article