[Influence of estrogen and progesterone on the vascular response to angiotensin-II in non-pregnant rabbit vessels--intact or denuded endothelium].
Nihon Sanka Fujinka Gakkai Zasshi
; 43(3): 281-8, 1991 Mar.
Article
em Ja
| MEDLINE
| ID: mdl-2045697
ABSTRACT
During pregnancy, vascular sensitivity to A-II is reduced and it was clarified that this refractoriness to A-II is due to a change in EDRF output in pregnant rabbits. The present study aimed at elucidating whether estrogen or progesterone is responsible for the augmentation of EDRF output. 17-OH-estradiol was administered (200 micrograms/kg/day) for 7 days to 8 non-pregnant rabbits, while progesterone was similarly administered (2,000 micrograms/kg/day) to 8 other non-pregnant rabbits. Twenty-four nonpregnant rabbits were employed as the controls. Common iliac arterial rings prepared from each group were compared for the isometric response to A-II. The arterial rings with intact endothelium prepared from the progesterone-treated group were found to have a smaller pD2 value and a smaller maximum response to A-II than the estrogen-treated group. On the other hand, no differences between the progesterone group and estradiol group were observed in these values for the endothelium-denuded arterial rings. These findings indicated that the augmentation of EDRF output during pregnancy is brought about by progesterone.
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Base de dados:
MEDLINE
Assunto principal:
Progesterona
/
Angiotensina II
/
Estrogênios
/
Contração Muscular
/
Músculo Liso Vascular
/
Óxido Nítrico
Idioma:
Ja
Ano de publicação:
1991
Tipo de documento:
Article