Syntheses and structure-activity relationship (SAR) studies of 2,5-diazabicyclo[2.2.1]heptanes as novel alpha7 neuronal nicotinic receptor (NNR) ligands.
Bioorg Med Chem Lett
; 20(12): 3636-9, 2010 Jun 15.
Article
em En
| MEDLINE
| ID: mdl-20472430
ABSTRACT
Biaryl substituted 2,5-diazabicyclo[2.2.1]heptanes have been synthesized and tested for their affinity toward alpha7 neuronal nicotinic receptors (NNRs). SAR studies established that 5-N-methyl substituent, heteroaryl linker and the nature of terminal aryl group are critical for the ligand to achieve potent alpha7 NNR agonist activity.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Agonistas Nicotínicos
/
Heptanos
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article