Increases in waist circumference and weight as predictors of type 2 diabetes in individuals with impaired fasting glucose: influence of baseline BMI: data from the DESIR study.
Diabetes Care
; 33(8): 1850-2, 2010 Aug.
Article
em En
| MEDLINE
| ID: mdl-20484131
ABSTRACT
OBJECTIVE:
To evaluate in impaired fasting glucose (IFG) the relative importance of increases in waist circumference and weight on progression to type 2 diabetes. RESEARCH DESIGN ANDMETHODS:
The 9-year incidence of diabetes was studied in 979 men and women with baseline IFG, from the Data from an Epidemiological Study on the Insulin Resistance Syndrome (DESIR) cohort.RESULTS:
Increases in both waist circumference and weight were significantly associated with diabetes incidence. Standardized odds ratios (95% CI) were 1.79 (1.45-2.21) and 1.86 (1.51-2.30), respectively, after controlling for baseline risk factors. The impact of waist circumference increase was greater for BMI <25 kg/m(2) (2.40 [1.63-3.52]) than for BMI >or=25 kg/m(2) (1.66 [1.28-2.16]) and persisted after adjusting for concurrent changes in either insulinemia or the homeostasis model assessment of insulin resistance index. Weight change had a similar impact in both BMI groups.CONCLUSIONS:
In individuals with IFG, it is important to monitor and prevent increases in waist circumference, in particular for those with BMI <25 kg/m(2).
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Glicemia
/
Peso Corporal
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Índice de Massa Corporal
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Jejum
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Diabetes Mellitus Tipo 2
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Circunferência da Cintura
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article