Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in adults characterized by high viral genome load within circulating natural killer cells.

Fox, C P; Shannon-Lowe, C; Gothard, P; Kishore, B; Neilson, J; O'Connor, N; Rowe, M

Fox, C P; Shannon-Lowe, C; Gothard, P; Kishore, B; Neilson, J; O'Connor, N; Rowe, M.

Afiliação

Fox CP; School of Cancer Sciences, University of Birmingham, Edgbaston, UK. c.p.fox@bham.ac.uk

Clin Infect Dis ; 51(1): 66-9, 2010 Jul 01.

Article em En | MEDLINE | ID: mdl-20504238

ABSTRACT

ABSTRACT

Epstein-Barr virus (EBV)-associated hemophagocytic lymphohistiocytosis (HLH) is a rare and aggressive disease usually encountered in the context of primary EBV infection. In most analyzed cases, EBV has been found predominantly in T cells. We describe the novel finding of high EBV genome numbers within circulating natural killer cells in adult patients with EBV-HLH.

Assuntos

Infecções por Vírus Epstein-Barr/complicações; Herpesvirus Humano 4/isolamento & purificação; Células Matadoras Naturais/virologia; Linfo-Histiocitose Hemofagocítica/virologia; Exame de Medula Óssea; Genoma Viral; Herpesvirus Humano 4/genética; Humanos; Masculino; Pessoa de Meia-Idade; Estudos Retrospectivos; Carga Viral; Adulto Jovem

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células Matadoras Naturais / Herpesvirus Humano 4 / Infecções por Vírus Epstein-Barr / Linfo-Histiocitose Hemofagocítica Idioma: En Ano de publicação: 2010 Tipo de documento: Article

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