[Study on the relationship between partial deletions in the azzospermia factor C region of Y chromosome and male infertility].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
; 27(3): 294-8, 2010 Jun.
Article
em Zh
| MEDLINE
| ID: mdl-20533269
ABSTRACT
OBJECTIVE:
To investigate the relationship between the partial deletions in the azzospermia factor(AZFc) region of Y chromosome and male infertility.METHODS:
Multiplex PCR technology was performed to screen the partial deletions in the AZFc region in 158 azoospermia, 160 severe oligozoospermia and 135 oligozoospermia patients and 236 men with normal spermatogenesis.For samples with gr/gr, b2/b3 recombinogenic deletions, author applied RFLP method to identify which DAZ gene doublet deletion was involved.RESULTS:
The gr/gr and b2/b3 were two types of common deletions detected. There were significant differences in the b2/b3 deletion in patients with oligozoospermia and severe oligozoospermia compared to the controls (both P< 0.05). However, there was no difference for the gr/gr deletion between the patients and controls.CONCLUSION:
The results suggested that the b2/b3 deletion might be a risk factor to spermatogenic impairment and might lead to male infertility.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Deleção de Sequência
/
Proteínas de Plasma Seminal
/
Cromossomos Humanos Y
/
Infertilidade Masculina
Idioma:
Zh
Ano de publicação:
2010
Tipo de documento:
Article