Age-dependent Mendelian predisposition to herpes simplex virus type 1 encephalitis in childhood.
J Pediatr
; 157(4): 623-9, 629.e1, 2010 Oct.
Article
em En
| MEDLINE
| ID: mdl-20553844
ABSTRACT
OBJECTIVE:
To test the hypothesis that predisposition to childhood herpes simplex virus (HSV) type 1 encephalitis (HSE) may be determined in part by human genetic factors. STUDYDESIGN:
A genetic epidemiologic survey of childhood HSE (onset at age 3 months to 15 years) over a 20-year period (1985-2004) was conducted throughout France (comprising 29 university hospital neuropediatric centers). A total of 85 children fulfilled the diagnostic criteria for inclusion. Family and personal histories were obtained by face-to-face interview for 51 patients.RESULTS:
No familial cases of HSE were identified in our survey; however, a high proportion (20%) of the children interviewed had a relevant family history parental consanguinity (12% of patients), early-onset herpetic keratitis in a first-degree relative (6%), or both (2%). The narrow window of high susceptibility to HSE before age 3 years (62% of patients) further indicates that predisposition to HSE is tightly age-dependent.CONCLUSIONS:
This survey suggests that childhood HSE, although sporadic, may result from Mendelian predisposition (from autosomal recessive susceptibility in particular), at least in some children. There likely is incomplete penetrance, however, which may reflect, at least in part, the impact of age at the time of HSV-1 infection.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Variação Genética
/
Encefalite por Herpes Simples
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Receptor 3 Toll-Like
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article