miRNAs as therapeutic targets in ischemic heart disease.
J Cardiovasc Transl Res
; 3(3): 280-9, 2010 Jun.
Article
em En
| MEDLINE
| ID: mdl-20560049
ABSTRACT
Ischemic heart disease is a form of congestive heart failure that is caused by insufficient blood supply to the heart, resulting in a loss of viable tissue. In response to the injury, the non-ischemic myocardium displays signs of secondary remodeling, like interstitial fibrosis and hypertrophy of cardiac myocytes. This remodeling process further deteriorates pump function and increases susceptibility to arrhythmias. MicroRNAs (miRNAs) are small, non-coding RNAs that regulate gene expression in a sequence-dependent manner. Recently, several groups identified miRNAs as crucial gene regulators in response to myocardial infarction (MI) and during post-MI remodeling. In this review, we discuss how modulation of these miRNAs represents a promising new therapeutic strategy to improve the clinical outcome in ischemic heart disease.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Terapia Genética
/
Isquemia Miocárdica
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MicroRNAs
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Miocárdio
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article