Increased level of arginase activity correlates with disease severity in HIV-seropositive patients.
J Infect Dis
; 202(3): 374-85, 2010 Aug 15.
Article
em En
| MEDLINE
| ID: mdl-20575659
ABSTRACT
Infection with human immunodeficiency virus (HIV) results in a chronic infection that progressively impairs the immune system. Although depletion of CD4(+) T cells is frequently used to explain immunosuppression, chronicity of infection and progressive loss of CD4(+) T cells are not sufficient to fully account for immune dysregulation. Arginase-induced l-arginine deprivation is emerging as a key mechanism for the down-regulation of immune responses. Here, we hypothesized that the level of arginase activity increases with disease severity in HIV-seropositive patients. We determined the levels of arginase activity in peripheral blood mononuclear cells from HIV-seropositive patients and uninfected control participants. Our results show that peripheral blood mononuclear cells from HIV-seropositive patients with low CD4(+) T cell counts expressed statistically significantly higher levels of arginase activity, compared with patients with high CD4(+) T cell counts or uninfected control participants. Furthermore, we found a statistically significant correlation between high level of arginase activity and high viral load in HIV-seropositive patients.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Arginase
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Índice de Gravidade de Doença
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Leucócitos Mononucleares
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Infecções por HIV
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article