Click-based synthesis and proteomic profiling of lipstatin analogues.
Chem Commun (Camb)
; 46(44): 8335-7, 2010 Nov 28.
Article
em En
| MEDLINE
| ID: mdl-20577697
ABSTRACT
Using click chemistry to enable both structural diversity and proteome profiling within a natural product derived library, two out of nineteen lipstatin analogues showed similar activity to Orlistat against fatty acid synthase (FAS), but with an improved ability to induce tumour cell death.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteoma
/
Ácido Graxo Sintases
/
Lactonas
/
Antineoplásicos
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article