Long-term benefit sustained after bilateral pallidal deep brain stimulation in patients with refractory tardive dystonia.
Stereotact Funct Neurosurg
; 88(5): 304-10, 2010.
Article
em En
| MEDLINE
| ID: mdl-20588082
ABSTRACT
BACKGROUND/AIMS:
Tardive dystonia (TD) can be a highly disabling, permanent condition related to the use of dopamine-receptor-blocking medications. Our aim was to evaluate the long-term effect of bilateral pallidal deep brain stimulation (DBS) for TD.METHODS:
Five consecutive patients with disabling TD who underwent stereotactic placement of bilateral globus pallidus internus DBS leads were included. All patients had a history of mood disorder or schizophrenia previously treated with neuroleptic medication, with a mean duration of motor symptoms of 10.2 years. Dystonia severity was measured using the Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS) movement score by a blinded neurologist reviewing pre- and postoperative videotaped examinations.RESULTS:
The mean baseline movement BFMDRS score was 49.7 (range 20-88). Overall, we observed a mean reduction of 62% in the BFMDRS movement score within the first year after surgery. Persistent improvement in dystonia (71%) was seen at the last follow-up ranging from 2 to 8 years after surgery.CONCLUSION:
Our experience suggests that pallidal DBS can be an effective therapy with long-term benefits for patients with TD.
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Base de dados:
MEDLINE
Assunto principal:
Antagonistas de Dopamina
/
Estimulação Encefálica Profunda
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Discinesia Induzida por Medicamentos
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Globo Pálido
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article