Heteroadamantyl cannabinoids.
J Med Chem
; 53(15): 5656-66, 2010 Aug 12.
Article
em En
| MEDLINE
| ID: mdl-20593789
ABSTRACT
The aliphatic side chain plays a pivotal role in determining the cannabinergic potency of tricyclic classical cannabinoids. We have synthesized a series of analogues in which the C3 position is substituted either directly or through a one-carbon atom linker with an adamantylamine or with an oxa- or an oxazaadamantane. The oxaadamantane pharmacophore in analogue 16 showed the best binding profile for both receptors.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Canabinoides
/
Adamantano
/
Receptor CB1 de Canabinoide
/
Receptor CB2 de Canabinoide
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article