Trigoxyphins A-G: diterpenes from Trigonostemon xyphophylloides.

ABSTRACT

Six new oxygenated daphnane-type diterpenoids, trigoxyphins A-F (1-6), a phenanthrene-type diterpenoid, trigoxyphin G (7), and two known compounds were isolated from twigs of Trigonostemon xyphophylloides. Their structures were established using spectroscopic methods. Compounds 1 and 2 exhibited strong cytotoxic activity against HL60 (IC(50) 0.27 and 0.49 microM) and A549 (IC(50) 7.5 and 4.9 microM) tumor cell lines, respectively.