Synthesis and biological evaluation of novel biotin-iminoalditol conjugates.
Bioorg Med Chem Lett
; 20(14): 4077-9, 2010 Jul 15.
Article
em En
| MEDLINE
| ID: mdl-20610152
ABSTRACT
Biotin-iminosugar conjugates of different configuration such as D-gluco, D-galacto, L-ido as well as a furanoid representative in the D-manno configuration have been synthesised and exhibit powerful inhibition of beta-glucosidase from Agrobacterium sp. with K(i) values in the range of the respective parent compounds. Such molecular probes have potential for activity-based protein profiling taking advantage of the biotin-(strept)avidin interaction.
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Base de dados:
MEDLINE
Assunto principal:
Álcoois Açúcares
/
Biotina
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article