Effects of Panax ginseng on glial cell-derived neurotrophic factor (GDNF) expression and spermatogenesis in rats.
Phytother Res
; 25(2): 308-11, 2011 Feb.
Article
em En
| MEDLINE
| ID: mdl-20625988
ABSTRACT
Panax ginseng (PG) is a medicinal herb which has been used to improve male reproduction in traditional Korean medicine. This study investigated the effect of PG on spermatogenesis and the regulation of glial cell-derived neurotrophic factor (GDNF), which has a crucial role in spermatogonial stem cell maintenance. PG was administered to 8-week-old male Wistar rats (1.0 g/kg/day, p.o.) for 56 consecutive days, the sperm formation period of the rat. Sperm analysis, RT-PCR and western blot assays were then carried out. The PG-treated group had significantly enhanced sperm counts, GDNF mRNA level and protein level. These results suggest that PG induces spermatogenesis and GDNF activation in rat testes.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Espermatogênese
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Fator Neurotrófico Derivado de Linhagem de Célula Glial
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Panax
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article