Facilitation of Ih channels by P2Y1 receptors activation in Mesencephalic trigeminal neurons.
Neurosci Lett
; 482(2): 156-9, 2010 Sep 27.
Article
em En
| MEDLINE
| ID: mdl-20643189
ABSTRACT
P2Y(1) receptors, a subset of G-protein coupled receptors, have been shown to participate in sensory transduction in the periphery nervous system. However, little is known about their sensory function in the central nervous system. Here, by using immunohistochemistry, we showed that P2Y(1) receptors are predominantly localized in the somata of Mesencephalic trigeminal neurons (Mes V neurons), the primary sensory neurons in brainstem. Whole-cell voltage-clamp recording revealed that ADP-beta-S, a P2Y receptor agonist, enhanced the activity of hyperpolarization-activated cation channels (Ih channels) in Mes V neurons and that the activity-enhancing effect of ADP-beta-S could be blocked by a specific P2Y(1) receptor antagonist, MRS 2179. Taken together, these results suggested a possible role of P2Y(1) receptors in the information transduction of central sensory neurons through regulating Ih channel activities.
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Base de dados:
MEDLINE
Assunto principal:
Células Receptoras Sensoriais
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Núcleos do Trigêmeo
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Canais de Potássio
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Canais de Cátion Regulados por Nucleotídeos Cíclicos
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Receptores Purinérgicos P2Y1
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article