Assessment of evidence for a protective role of vitamin D in multiple sclerosis.
Biochim Biophys Acta
; 1812(2): 202-12, 2011 Feb.
Article
em En
| MEDLINE
| ID: mdl-20674744
ABSTRACT
Evidence for a role of vitamin D insufficiency in determining risk in Multiple Sclerosis (MS) is supported by studies in both pediatric- and adult-onset patients. The potential role of vitamin D in modulating MS disease activity is an area of active clinical trials research, and the possibility of primary disease prevention with vitamin D supplementation in early life is an emerging concept. With Sir Austin Bradford Hill's criteria as a framework, the present review assesses the evidence for a causal relationship between vitamin D insufficiency and the pathobiology of MS, and discusses rationale for future clinical trials with vitamin D.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Vitamina D
/
Esclerose Múltipla
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article