Macrophage migration inhibitory factor plays a pivotal role in hepatocellular carcinoma and may be a noninvasive imaging target.
Med Hypotheses
; 75(6): 530-2, 2010 Dec.
Article
em En
| MEDLINE
| ID: mdl-20678866
ABSTRACT
Macrophage migration inhibitory factor (MIF) has emerged to play a central role in the control of the host inflammatory and immune response. Several reports have documented that MIF can inactivate the tumor suppresser activity of p53; overexpression of MIF was significantly higher in both the sera and the local lesions from patients with HCC than from patients with normal controls. These findings indicate that MIF may contribute to multiple aspects of tumor progression and neoplasia, thus MIF may be an effective therapeutic target molecule. We speculate that MIF is important for the development and progression of hepatocellular carcinoma, and can be used as a marker for tumor detection.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Biomarcadores Tumorais
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Fatores Inibidores da Migração de Macrófagos
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Carcinoma Hepatocelular
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Oxirredutases Intramoleculares
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Neoplasias Hepáticas
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article