A novel inhibitor of IL-1 generation, E5090: in vitro inhibitory effects on the generation of IL-1 by human monocytes.
Agents Actions Suppl
; 32: 225-9, 1991.
Article
em En
| MEDLINE
| ID: mdl-2069091
ABSTRACT
E5090 is an orally active inhibitor of IL-1 generation, being converted in vivo into the pharmacologically active deacetylated form (DA-E5090). In vitro effects of DA-E5090 on the generation of IL-1 by human monocytes stimulated with LPS were examined. DA-E5090 inhibited both IL-1 alpha and IL-1 beta generation by human monocytes stimulated with 1 microgram/ml of LPS in a dose dependent-manner (1-10 microM), as determined by LAF assay and ELISA. Northern blotting analysis indicated that DA-E5090 inhibits transcription of IL-1 alpha and IL-1 beta m-RNAs.
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Base de dados:
MEDLINE
Assunto principal:
Acrilatos
/
Monócitos
/
Anti-Inflamatórios não Esteroides
/
Interleucina-1
/
Naftóis
Idioma:
En
Ano de publicação:
1991
Tipo de documento:
Article