Complement regulator CD46 temporally regulates cytokine production by conventional and unconventional T cells.
Nat Immunol
; 11(9): 862-71, 2010 Sep.
Article
em En
| MEDLINE
| ID: mdl-20694009
ABSTRACT
In this study we demonstrate a new form of immunoregulation engagement on CD4(+) T cells of the complement regulator CD46 promoted the effector potential of T helper type 1 cells (T(H)1 cells), but as interleukin 2 (IL-2) accumulated, it switched cells toward a regulatory phenotype, attenuating IL-2 production via the transcriptional regulator ICER/CREM and upregulating IL-10 after interaction of the CD46 tail with the serine-threonine kinase SPAK. Activated CD4(+) T cells produced CD46 ligands, and blocking CD46 inhibited IL-10 production. Furthermore, CD4(+) T cells in rheumatoid arthritis failed to switch, consequently producing excessive interferon-gamma (IFN-gamma). Finally, gammadelta T cells, which rarely produce IL-10, expressed an alternative CD46 isoform and were unable to switch. Nonetheless, coengagement of T cell antigen receptor (TCR) gammadelta and CD46 suppressed effector cytokine production, establishing that CD46 uses distinct mechanisms to regulate different T cell subsets during an immune response.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Linfócitos T CD4-Positivos
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Regulação da Expressão Gênica
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Citocinas
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Proteína Cofatora de Membrana
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article