Association of ABCB1 polymorphisms with the efficacy of ondansetron for postoperative nausea and vomiting.
Anaesthesia
; 65(10): 996-1000, 2010 Oct.
Article
em En
| MEDLINE
| ID: mdl-20707787
ABSTRACT
We investigated whether the 2677G>T/A and 3435C>T polymorphisms of adenosine triphosphate-binding cassette subfamily B member 1 (ABCB1) affect the efficacy of ondansetron to prevent postoperative nausea and vomiting. One hundred and ninety-eight patients undergoing general anaesthesia were enrolled. Thirty minutes before the end of surgery, 0.1 mg.kg⻹ ondansetron was administered intravenously. The incidence of postoperative nausea and vomiting was compared between genotypes in the 2677G>T/A and 3435C>T polymorphisms of ABCB1. The incidence of postoperative nausea and vomiting was lower in patients with the 2677TT genotype (TT vs Non-TT = 25.9% vs 53.0%, p = 0.01) and 3435TT genotype (CC + CT vs TT = 52.6% vs 21.7%, p = 0.01) during the first 2 h after surgery. There were no significant differences in the incidence of postoperative nausea and vomiting between the different genotype groupings during period between 2 and 24 h after surgery. In conclusion, ABCB1 genotypes may be a clinical predictor of responsiveness for ondansetron.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Polimorfismo Genético
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Ondansetron
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Membro 1 da Subfamília B de Cassetes de Ligação de ATP
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Náusea e Vômito Pós-Operatórios
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Antieméticos
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article